COG categories Subcellular Location GC percentage Translation, ribosomal structure and biogenesis RNA processing and modification Transcription Replication, recombination and repair Chromatin structure and dynamics Cell cycle control, cell division, chromosome partitioning Nuclear structure Defense mechanisms Signal transduction mechanisms Cell wall/membrane/envelope biogenesis Cell motility Cytoskeleton Extracellular structures Intracellular trafficking, secretion, and vesicular transport Posttranslational modification, protein turnover, chaperones Energy production and conversion Carbohydrate transport and metabolism Amino acid transport and metabolism Nucleotide transport and metabolism Coenzyme transport and metabolism Lipid transport and metabolism Inorganic ion transport and metabolism Secondary metabolites biosynthesis, transport and catabolism General function prediction only Function unknown Cytoplasmic Cytoplasmic Membrane Outer Membrane Extracellular Cellwall Periplasmic Unknown > 0.75% 0.50% < 0.25%